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早期干預在新生兒缺氧缺血性腦病患兒中的應用效果

作者:未知

  [摘要]目的 探討早期干預在新生兒缺氧缺血性腦病(HIE)患兒中的應用效果。方法 選取2015年1月~2017年12月我院收治的70例新生兒HIE患兒作為研究對象,按照隨機數字表法分為對照組(35例)和研究組(35例)。對照組采用常規對癥治療方法,研究組采用常規對癥治療方法聯合早期干預。比較兩組的干預后智力發育指數(MDI)、心理運動發育(PDI)評分,12個月齡時總發育商(DQ)水平,干預后6周頭圍、身長、體重增長情況及隨訪6個月后遺癥發生情況。結果 研究組干預6個月MDI評分[(90.50±10.10)分]、干預12個月MDI評分[(96.20±10.70)分]均高于對照組,差異有統計學意義(P<0.05);研究組干預6個月PDI評分[(88.35±10.55)分]、干預12個月PDI評分[(91.45±13.10)分],與對照組比較,差異無統計學意義(P>0.05);研究組12個月齡時DQ水平包括大運動評分[(95.20±3.55)分]、精細動作評分[(84.30±9.70)分]、社交行為評分[(89.35±6.65)分]、適應能力評分[(82.80±8.45)分]、語言能力評分[(78.50±3.50)分]均高于對照組,差異有統計學意義(P<0.05);研究組干預后6周頭圍增長[(4.20±1.60)cm]、身長增長[(6.10±1.75)cm]、體重增長[(2.30±0.45)kg]均高于對照組,差異有統計學意義(P<0.05);研究組干預隨訪6個月后遺癥總發生率(2.86%)低于對照組,差異有統計學意義(P<0.05)。結論 對新生兒HIE患兒實施早期干預,可以明顯提高其智力和運動功能及預后。
  [關鍵詞]早期干預;新生兒;缺氧缺血性腦病;智力;運動功能;預后;效果
  [中圖分類號] R722.1          [文獻標識碼] A          [文章編號] 1674-4721(2019)10(b)-0115-04
  [Abstract] Objective To explore the application effect of early intervention on neonatal hypoxic-ischemic encephalopathy(HIE). Methods 70 cases of neonatal HIE admitted to our hospital from January 2015 to December 2017 were selected as the research objects. They were divided into control group (35 cases) and research group (35 cases) according to the random number table method. The control group was treated with routine symptomatic treatment, while the research group was treated with routine symptomatic treatment combined with early intervention. The dry prognosis mental development index (MDI), psychomotor development (PDI) score, total developmental quotient (DQ) level at 12 months old, head circumference, body length, body mass increase at 6 weeks after intervention and the occurrence of sequelae after 6 months of follow-up were compared between the two groups. Results The MDI score in the research group at 6 months of intervention ([90.50±10.10] points) and at 12 months of intervention ([96.20±10.70] points) were higher than those in the control group, and the difference was statistically significant (P<0.05). PDI score of the research group after 6 months of intervention ([88.35±10.55] points), PDI score of the research group after 12 months of intervention ([91.45±13.10] points), there was no significant difference between the two groups (P>0.05). The DQ level of the research group at 12 months old included big sport score ([95.20±3.55] points), fine motor score ([84.30±9.70] points), social behavior score ([89.35±6.65] points),  adaptability score ([82.80±8.45] points), the scores of language ability ([78.50±3.50] pointes) were higher than those of the control group, the differences were statistically significant (P>0.05). The head circumference of the research group increased 6 weeks after intervention ([4.20±1.60] cm), growth in length ([6.10±1.75] cm), weight gain ([2.30±0.45] kg) were higher than those of the control group, the differences were statistically significant (P>0.05). The total incidence of sequelae after 6 months follow-up in the research group (2.86%) was lower than that in the control group (P<0.05). Conclusion Early intervention in neonates with HIE can significantly improve their intelligence and motor function and prognosis.
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